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Stefan de Folter (CV)

Professor (3-E, SNI 2)

Stefan de Folter (CV)


Professor (3-E, SNI 2)


Functional Genomics of Plant Development


stefan.defolter (at) cinvestav mx


52 (462) 166-3000, ext 3011


2007-current: Professor at LANGEBIO, CINVESTAV-IPN, Irapuato, Mexico
2006-2007: Postdoc (Junior Researcher) at Plant Research International, Wageningen University & Research Centre, The Netherlands
2006: Working visit (two months) to the group of Dr. Elena Alvarez Buylla, Institute of Ecology, UNAM, Mexico
2000-2006: Senior Research Assistant, Plant Research International, Wageningen, The Netherlands
1998-2000: Research Assistant, Plant Research International, Wageningen, The Netherlands


2006: Ph.D. in Sciences, Radboud University Nijmegen, The Netherlands
1998: B.Sc. in Plant Biotechnology, Larenstein College, Velp, The Netherlands


2015: Research Award of the Mexican Academy of Sciences in the Area of Natural Sciences. Highest Mexican Award for Young Scientists. (Premio de Investigación - Academia Mexicana de Ciencias (AMC))
2015: Scholarship of the Marine Biological Laboratory (MBL), Woods Hole, USA.
2014: Member of Faculty of 1000, invited faculty member.
2008: “North American Arabidopsis Steering Committee-sponsored: International Registration Awards”, July 2008, congress visit: 19th International Conference on Arabidopsis Research, Montreal, Canada.
2006: Traveling Fellowship of The Company of Biologists (Development), Jan-Feb 2006, working visit to the group of Dr. E. Alvarez-Buylla, Institute of Ecology, UNAM, Mexico DF, Mexico.
2005: Traveling Fellowship of the LEB-fonds Wageningen, The Netherlands, June 2005, congress visit: 16th International Conference on Arabidopsis Research, Madison, Wisconsin, US.
2004: Traveling Fellowship of the LEB-fonds Wageningen, The Netherlands, July 2004, congress visit: 15th International Conference on Arabidopsis Research, Berlin, Germany.
2003: Traveling Fellowship of the LEB-fonds Wageningen, The Netherlands, April 2003, congress visit: 14th International Conference on Arabidopsis Research, Madison, Wisconsin, US.


Link to ResearchGate

Link to Citations Google Scholar


1. Reyes-Olalde JI, Zúñiga-Mayo VM, Serwatowska J, Chavez Montes RA, Lozano-Sotomayor P, Herrera-Ubaldo H, Gonzalez-Aguilera, KL, Ripoll, JJ, Ezquer, I, Paolo, D, Heyl, A, Colombo, L, Yanofsky, MF, Ferrandiz, C, Marsch-Martinez, N, de Folter, S (2017) The bHLH transcription factor SPATULA enables cytokinin signaling, and both activate auxin biosynthesis and transport genes at the medial domain of the gynoecium. PLoS Genetics 13: e1006726.
2. Rosas-Cardenas, FdeF. and de Folter, S. (2017) Conservation, divergence, and abundance of miRNAs and their effect in plants. In: Plant Epigenetics, RNA Technologies. Editors: Rajewsky, N., Jurga, S., Barciszewski J. Springer International Publishing. Pp. 1-22.

3. González-Morales, S.I., Chávez-Montes, R.A., Hayano-Kanashiro C., Alejo-Jacuinde, G., Rico-Cambron, T.Y., de Folter, S., and Herrera-Estrella, L. (2016) Regulatory network analysis reveals novel regulators of seed desiccation tolerance in Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA. E5232–E5241.
4. González-Aguilera, K.L., Farias Saad, C., Chávez Montes, R.A., Alves-Ferreira, M., de Folter, S. (2016) Selection of Reference Genes for Quantitative Real-Time RT-PCR Studies in Tomato Fruit of the Genotype MT-Rg1. Frontiers in Plant Science, 7: 1386.
5. Lozano-Sotomayor, P., Chávez Montes, R.A., Silvestre-Vañó, M., Herrera-Ubaldo, H., Greco, R., Pablo-Villa, J., Galliani, B.M., Diaz-Ramirez, D., Weemen, M., Boutilier, K., Pereira, A., Colombo, L., Madueño, F., Marsch-Martinez, N., and de Folter, S. (2016). Altered expression of the bZIP transcription factor DRINK ME affects growth and reproductive development in Arabidopsis thaliana. The Plant Journal, in press. DOI: 10.1111/tpj.13264
6. de Folter, S. (2016) Auxin is required for valve margin patterning in Arabidopsis, after all. Molecular Plant, 9: 768-770.
7. Chávez Montes, R.A., Serwatowska, J., de Folter, S. (2016) Laser assisted microdissection to study global transcriptional changes during plant embryogenesis. In: Somatic Embryogenesis: Fundamental Aspects and Application. Editors: Loyola-Vargas, Víctor M; Ochoa-Alejo, Neftalí. Springer International Publishing. doi: 10.1007/978-3-319-33705-0_27, in press.
8. Guzmán-López J.A., Abraham-Juárez M.J., Lozano-Sotomayor P., de Folter S., Simpson J. (2016) Arabidopsis thaliana gonidialess A/Zuotin related factors (GlsA/ZRF) are essential for maintenance of meristem integrity. Plant Mol Biol, doi: 10.1007/s11103-016-0439-x.
9. Marsch-Martínez, N., de Folter, S. (2016) Hormonal control of the development of the gynoecium. Curr Opin Plant Biol, 29:104-114.


10. Chávez Montes, R.A., Herrera-Ubaldo, H., Serwatowska, J., de Folter, S. (2015) Towards a comprehensive and dynamic gynoecium gene regulatory network. Current Plant Biology, 3-4: 3-12.
11. Reyes-Olalde, J.I., Marsch-Martínez, N., de Folter, S. (2015) Imaging early stages of the female reproductive structure of Arabidopsis by confocal laser scanning microscopy. Developmental Dynamics, 244: 1286-1290.
12. Sotelo-Silveira, M., Chauvin, A-L., Marsch-Martínez, N., Winkler, R., de Folter, S. (2015) Metabolic fingerprinting of Arabidopsis thaliana accessions. Frontiers in Plant Science, 6: 365.
13. González Muñoz, E., Avendaño-Vázquez, A-O., Chávez Montes, R.A., de Folter, S., Andrés-Hernández, L., Abreu-Goodger, C., Sawers, R.J. (2015) The maize (Zea mays ssp. mays var. B73) genome encodes 33 members of the purple acid phosphatase gene family. Frontiers in Plant Science, 6: 341.
14. Rosas-Cárdenas, F.F., Escobar-Guzmán, R., Cruz-Hernández, A., Marsch-Martínez, N., de Folter, S (2015) An efficient method for miRNA detection and localization in crop plants. Frontiers in Plant Science, 6: 99.
15. Pérez-Ruiz, R.V., García-Ponce, B., Marsch-Martínez, N., Ugartechea-Chirino, Y., Villajuana-Bonequi, M., de Folter, S., Azpeitia, E., Dávila-Velderrain, J., Cruz-Sánchez, D., Garay-Arroyo, A., de la Paz Sánchez, M., Estévez-Palmas, J.M., Alvarez-Buylla, E.R. (2015) XAANTAL2 (AGL14) is an important component of the complex gene regulatory network that underlies Arabidopsis shoot apical meristem transitions. Molecular Plant, 8: 796-813.
16. Rosas-Cárdenas, F.F., Caballero-Pérez, J., Gutiérrez-Ramos, X., Marsch-Martínez, N., Cruz-Hernández, A., de Folter, S. (2015) miRNA expression during prickly pear cactus fruit development. Planta, 241: 435-448.

17. Marsch-Martínez, N., Zúñiga-Mayo, V.M., Herrera-Ubaldo, H., Ouwerkerk, P.B.F., Lozano-Sotomayor, P., Greco, R., Ballester, P., Balanzá, V., Pablo-Villa, J., Kuijt, S.J.H., Meijer, A.H., Pereira, A., Ferrándiz, C., de Folter, S. (2014) The NTT transcription factor positively regulates replum development in Arabidopsis fruits. The Plant Journal, 80: 69-81.
18. Chávez Montes, R.A., Rosas-Cárdenas, FF, De Paoli, E., Accerbi, M., Rymarquis, L.A., Mahalingam, G., Marsch-Martínez, N., Meyers, B.C., Green, P.J., de Folter, S. (2014) Sample sequencing of vascular plants demonstrates widespread conservation and divergence of microRNAs. Nature Communications, 5: 3722.
19. Zúñiga-Mayo, V.M., Reyes-Olalde, J.I., Marsch-Martinez, N., de Folter, S. (2014) Cytokinin treatments affect the apical-basal patterning of the Arabidopsis gynoecium and resemble the effects of polar auxin transport inhibition. Frontiers in Plant Science, 5: 191.
20. Chávez Montes, R.A., Coello, G., González-Aguilera, K.L., Marsch-Martínez, N., de Folter, S., Alvarez-Buylla, E.R. (2014) ARACNe-based inference, using curated microarray data, of Arabidopsis thaliana root transcriptional regulatory networks. BMC Plant Biology, 14: 97.
21. Sotelo-Silveira, M., Marsch-Martínez, N., de Folter S. (2014) Unraveling the signal scenario of fruit set. Planta, 239:1147-1158.
22. Espinosa-Soto, C., Immink R.G.H., Angenent, G.C., Alvarez-Buylla, E.R. *, de Folter, S. * (2014) Tetramer formation in Arabidopsis MADS domain proteins: Analysis of a protein-protein interaction network. BMC Syst Biol, 8: 9.
23. Herrera-Ubaldo, H., Zanchettia, E., Colombo, L., de Folter, S. (2014) Protein interactions guiding carpel and fruit development in Arabidopsis. Plant Biosystems, 148:169-175.

24. Danisman S., van Dijk A.D., Bimbo A., van der Wal F., Hennig L., de Folter S., Angenent G.C., Immink R.G. (2013) Analysis of functional redundancies within the Arabidopsis TCP transcription factor family. Journal of Experimental Botany, 64: 5673-5685.
25. Garay-Arroyo A., Ortiz-Moreno E., de la Paz Sánchez M., Murphy A.S., García-Ponce B., Marsch-Martínez N., de Folter S., Corvera-Poiré A., Jaimes-Miranda F., Pacheco-Escobedo M.A., Dubrovsky J.G., Pelaz S., Alvarez-Buylla E.R. (2013) The MADS transcription factor XAL2/AGL14 modulates auxin transport during Arabidopsis root development by regulating PIN expression. EMBO Journal, 32: 2783-2895.
26. Reyes-Olalde J.I., Zuñiga-Mayo V.M., Chávez Montes R.A., Marsch-Martínez N., de Folter S. (2013) Inside the gynoecium: at the carpel margin. Trends in Plant Science, 18: 644-655.
27. Sotelo-Silveira, M., Cucinotta, M., Colombo, L., Marsch-Martínez, N., de Folter, S. (2013) Towards understanding the role of CYP78A9 during Arabidopsis reproduction. Plant Signaling & Behaviour, 8 (8): e25160.
28. Marsch Martínez, N., Franken, J., Gonzalez-Aguilera, K.L., de Folter, S., Angenent, G.C., Alvarez-Buylla, E.R. (2013) An efficient flat-surface collar-free grafting method for Arabidopsis thaliana seedlings. Plant Methods, 9(1): 14.
29. Sotelo-Silveira, M., Cucinotta, M., Chauvin, A-L, Chávez Montes, R.A., Colombo, L., Marsch-Martínez, N., de Folter, S. (2013) Cytochrome P450 CYP78A9 is involved in Arabidopsis reproductive development. Plant Physiology, 162: 779-799.
30. de los Santos-Villalobos, S., de Folter, S., Délano-Frier, J.P., Gómez-Lim, M.A., Guzmán-Ortiz, D.A., Peña-Cabriales, J.J. (2013) Growth Promotion and Flowering Induction in Mango (Mangifera indica L. cv \'\'Ataulfo\'\') Trees by Burkholderia and Rhizobium Inoculation: Morphometric, Biochemical, and Molecular Events. Journal of Plant Growth Regulation, 32: 615–627.
31. de los Santos-Villalobos, S., Guzman-Ortiz, D.A., Gomez-Lim, M.A., Delano-Frier, J.P., de Folter, S., Sanchez-Garcia, P., Pena-Cabriales J.J. (2013) Potential use of Trichoderma asperellum (Samuels, Liechfeldt et Nirenberg) T8a as a biological control agent against anthracnose in mango (Mangifera indica L.). Biological Control, 64: 37- 44.

32. Marsch-Martinez, N., Reyes-Olalde, J.I., Ramos-Cruz, D., Lozano-Sotomayor, P., Zuniga-Mayo, V.M., and de Folter, S. (2012) Hormones talking: Does hormonal crosstalk shape the Arabidopsis gynoecium? Plant Signaling & Behaviour, 7: 12, 1-4.
33. Zuniga-Mayo, V.M., Marsch-Martinez, N., and de Folter, S. (2012) The class II HD-ZIP JAIBA gene is involved in meristematic activity and important for gynoecium and fruit development in Arabidopsis. Plant Signaling & Behaviour, 7: 11, 1-3.
34. de los Santos-Villalobos, S., Parra-Cota, F.I., de Folter, S., and Pena-Cabriales, J.J. (2012) Primers to amplify flowering locus T (FT) transcript in mango (Mangifera indica) and their potential use in other angiosperms. Plant Omics Journal, 5: 453-457.
35. Immink R.G.H., Pose D., Ferrario, S., Ott, F., Kaufmann, K., Leal Valentim, F., de Folter, S., van der Wal, F., van Dijk, A.D.J., Schmid, M., and Angenent, G.C. (2012) Characterization of SOC1’s Central Role in Flowering by the Identification of Its Upstream and Downstream Regulators. Plant Physiology, 160: 433-449.
36. Danisman, S., van der Wal, F., Dhondt, S., Waites, R., de Folter, S., Bimbo, A., van Dijk, A.D.J., Muino, J., Cutri, L., Dornelas, M., Angenent, G.C., and Immink, R.G.H. (2012) Arabidopsis class I and class II TCP transcription factors regulate jasmonic acid metabolism and leaf development antagonistically. Plant Physiology, 159: 1511-1523.
37. Marsch-Martinez, N., Ramos-Cruz, D., Reyes-Olalde, J.I., Lozano-Sotomayor, P., Zuniga-Mayo, V.M., and de Folter, S. (2012) The role of cytokinin during Arabidopsis gynoecia and fruit morphogenesis and patterning. The Plant Journal, 72: 222-234.
38. Zuniga-Mayo, V.M., Marsch-Martinez, N., and de Folter, S. (2012) JAIBA, a class II HD-ZIP transcription factor involved in the regulation of meristematic activity and important for correct gynoecium and fruit development in Arabidopsis. The Plant Journal, 71: 314-326.
39. Campos-Guillén, J., Cruz-Medina, J.A., Pastrana-Martínez, X., Guevara-González, R.G., Torres-Pacheco, I., Mondragón-Jacobo, C., Gutiérrez-Martínez, P., de Folter, S., Cruz-Hernández, A. (2012) Molecular analysis in prickly pear ripening: An overview. Israel Journal of Plant Sciences, 60: 349 – 357.

40. Marsch-Martínez, N., Wenwu, W., and de Folter, S. (2011) The MADS symphonies of transcriptional regulation. Frontiers in Plant Science, 2: 26, doi: 10.3389/fpls.2011.00026.
41. Escobar-Guzmán, R., de Folter, S., and Marsch-Martínez, N. (2011) Hot and retro meet Arabidopsis. Frontiers in Plant Science, 2: 22, doi: 10.3389/fpls.2011.00022.
42. Rosas-Cárdenas, F.F., Durán-Figueroa, N., Vielle-Calzada, J-P, Cruz-Hernández, A., Marsch-Martínez, N., and de Folter, S. (2011) A simple and efficient method for isolating small RNAs from different plant species. Plant Methods, 7:4.
43. Wenwu, W., de Folter, S., Shen, X., Zhang, W., and Tao, S. (2011) Vertebrate paralogous MEF2 genes: origin, conservation, and evolution. PLoS ONE, 6 (3): e17334.
44. de los Santos-Villalobos, S., de Folter, S., Délano-Frier, J.P., Gómez-Lim, M.A., Guzmán-Ortiz, D.A., Sánchez-García, P., Peña-Cabriales J.J. (2011) Critical aspects on the integral Management of mango (Mangifera indica): Flowering, anthracnose, and industrial waste. Revista mexicana de ciencias agrícolas, 2 (2): 221-234.
45. Wenwu W., Xiaotai, H., Cheng, J., Li, Z., de Folter, S., Huang, Z., Jiang, X., Pang, H., and Tao, S. (2011) Conservation and evolution in and among SRF -and MEF2-type MADS domains and their binding sites. Mol Biol Evo, 28, 501-511.
46. de Folter, S. and Immink, R.G.H. (2011) Yeast protein-protein interaction assays and screens. In: Plant Transcription Factors. Series: Methods in Molecular Biology. Editors: Sharyn Perry and Ling Yuan. Humana Press Inc. NY, USA. 754: 145-165.
47. de Folter, S. (2011) Protein Tagging for Chromatin Immunoprecipitation (ChIP) from Arabidopsis. In: Plant Reverse Genetics. Series: Methods in Molecular Biology. Editor: Andy Pereira. Humana Press Inc. NY, USA. 678: 199-210.

48. Alvarez-Buylla, E.R., Benítez, M., Corvera-Poiré, A., Chaos Cador, A., de Folter, S., Gamboa de Buen, A, Garay-Arroyo, A, García-Ponce, B., Jaimes-Miranda, F., Pérez-Ruiz, R.V., Piñeyro-Nelson, A., Sánchez-Corrales, Y.E. (2010) Flower Development. In: The Arabidopsis Book. Rockville, MD: The American Society of Plant Biologists. doi: 10.1199/tab.0127, http://www.aspb.org/publications/arabidopsis/

49. Immink, R.G.H.*, Nougalli Tonaco, I.*, de Folter, S., Shchennikova, A., van Dijk A.D.J., Busscher-Lange, J., Mooyman, P., Borst, J-W., and Angenent G.C. (2009) SEPALLATA3: The “glue” for MADS box transcription factor complex formation. Genome Biology, 10, R24.
50. Urbanus, S., de Folter, S., Shchennikova, A., Kaufmann, K., Immink, R.G.H., and Angenent, G.C. (2009) In planta localisation patterns of MADS domain proteins during floral development in Arabidopsis thaliana. BMC Plant Biology, 9, 5.
51. Marsch-Martínez, N., Zúñiga Mayo, V.M., Reyes Olalde, J.I., Salazar Moya, O.R., y de Folter, S. (2009) Genómica Funcional de Plantas: Estudio del desarrollo de flores y frutos. Acta Universitaria, 19: 21-29. (en español)

52. Verelst, W., Twell, D., de Folter, S., Immink, R.G.H., Saedler, H., Münster, T. (2007) MADS-complexes regulate transcriptome dynamics during pollen maturation. Genome Biology, 8, R249.
53. de Folter, S., Urbanus, S.L., van Zuijlen, L.G.C., Kaufmann, K., and Angenent, G.C. (2007) Tagging of MADS domain proteins for chromatin immunoprecipitation. BMC Plant Biology, 7, 47.

54. de Folter, S., Shchennikova, A.V., Franken, J., Busscher, M., Baskar, R., Grossniklaus, U., Angenent, G.C., and Immink, R.G.H. (2006) Two closely related MADS box genes in petunia and in Arabidopsis involved in ovule and seed development. The Plant Journal, 47, 934-946.
55. Marsch-Martinez, N.*, Greco, R.*, Becker, J.D., Dixit, S., Bergervoet, J.H.W., Karaba, A., de Folter, S., and Pereira, A. (2006) BOLITA, an Arabidopsis AP2/ERF-like transcription factor that affects cell expansion and proliferation/differentiation pathways. Plant Molecular Biology, 62, 825-843.
56. de Folter, S. and Angenent, G.C. (2006) Trans meets cis in MADS science. Trends in Plant Science, 11, 224-231.
57. Syed Alwee, S., van der Linden, C.G., van der Schoot, J., de Folter, S., Angenent, G.C., Cheah, S-C., Smulders, M.J.M. (2006) Molecular characterization of flower development in oil palm in relation to the mantling abnormality. Plant Cell, Tissue and Organ culture, 85, 331-344.
58. Ciannamea, S., Busscher-Lange, J., de Folter, S., Angenent, G.C., and Immink, R.G.H. (2006) Characterization of the vernalization response in Lolium perenne by a cDNA microarray approach. Plant and Cell Physiology, 47, 481- 492.

59. de Folter, S., Immink, R.G.H., Kieffer, M., Pařenicová, L. Henz, S.R., Weigel, D., Busscher, M., Kooiker, M., Colombo, L., Kater, M.M., Davies, B., and Angenent, G.C. (2005) Comprehensive interaction map of the Arabidopsis MADS box transcription factors. The Plant Cell, 17, 1424-1433.
60. Gómez-Mena, C., de Folter, S., Costa, M.M.R., Angenent, G.C., and Sablowski, R. (2005) Transcriptional program controlled by the floral homeotic gene AGAMOUS during early organogenesis. Development, 132, 429-438.

61. de Folter, S., Busscher, J., Colombo, L., Losa, A., and Angenent, G.C. (2004) Transcript profiling of transcription factor genes during silique development in Arabidopsis. Plant Molecular Biology, 56, 351-366.

62. Pařenicová, L.*, de Folter, S.*, Kieffer, M.*, Horner, D.S., Favalli, C., Busscher, J., Cook, H.E., Ingram, R.M., Kater, M.M., Davies, B., Angenent, G.C., and Colombo, L. (2003) Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: New openings to the MADS world. The Plant Cell, 15, 1538-1551.

63. Assunção, A.G.L., Da Costa Martins, P., de Folter, S., Vooijs, R., Schat, H., and Aarts, M.G.M. (2001) Elevated expression of metal transporter genes in three accessions of the metal hyperaccumulator Thlaspi caerulescens. Plant, Cell and Environment, 24, 217-226.


64. de Folter, S. (2010). MADS Box Genes in Arabidopsis: A family characterization. VDM Verlag Dr. Muller Aktiengesellschaft & Co., Alemania, ISBN: 978-3639245219, 244 pages. http://www.amazon.com/


1. Cristina G. Reynaga Peña, Nayelli Marsch Martínez, Stefan de Folter y Axel Tiessen Favier (2015) Materiales audiovisuales con experimentos lúdicos de biología: una forma eficaz de entusiasmar a los niños y a los maestros por la ciencia. En: Los procesos de divulgación y apropiación social de la ciencia y la tecnología: pasos hacia la construcción de la cultura científica en Guanajuato. Coordinadores: Mayra Morales Tirado y Antonio Vega Corona. Consejo de Ciencia y Tecnología del Estado de Guanajuato. Guanajuato, Gto., México. ISBN: 978-607-8164-03-5. Páginas: 111-132.
2. Rosas-Cárdenas, F.F., Luna-Suárez, S., de Folter, S. (2014) El importante papel de los miRNAs en plantas de interés agronómico. Frontera Biotecnológica, CIBA-IPN, 1: 26-35.
3. Chávez Montes, R.A., de Folter S. (2013) Secuenciacion masiva de microARNs: ¿qué haríamos sin las computadoras? Ide@s CONCYTEG 8(95): 489-493, ISSN: 2007-2716.
4. González-Aguilera K.L., de Folter, S. (2013) ¿Para qué sirve la biología computacional en la ciencia básica de plantas? Ide@s CONCYTEG 8(95): 481-487, ISSN: 2007-2716.
5. Marsch-Martínez, N. y de Folter, S. (2010) Arabidopsis, un ”pequeño” gran genoma. Gaceta Genómica de la Universidad Autónoma de la Ciudad de México, Número 7, enero-abril.
6. Marsch-Martínez, N. y de Folter, S. (2010) DVD educativa para escuelas rurales: “Flores y frutos: Biodiversidad en acción”. Taller de Ciencia para niñas y niños, volumen 3. Parte del proyecto de CONCyTEG: “Siente la ciencia” de la Dra. Cristina Reynaga, CINVESTAV-Irapuato. Sponsered by the American Society of Plant Biologists (ASPB).
7. de Folter, S. y Marsch-Martinez, N. (2007) Redes de control transcripcional en plantas. Gaceta Ide@s Concyteg, 29: 58-63.

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